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Glutathione / NADPH
IDH1/IDH2 NADPH-Generation Terrain
Cytosolic and mitochondrial NADPH context with oncology-safety boundaries.
Evidence quality visible
No dosing or treatment advice
Terrain context linked
What The Enzyme Does
IDH1 and IDH2 are represented as NADPH-generation context nodes. The page avoids oncology interpretation and mutation-specific clinical claims.
- Gene
- Isocitrate dehydrogenase 1 and 2
- External IDs
- MetaboliQ:condition:idh1-idh2
What The Variants Change
IDH1/IDH2 controls are blocked until curated variant records, graph edges, and reviewer signoff exist.
No curated variant control is exposed for IDH1/IDH2 in Phase 1A.
Downstream Consequences
- IDH1/IDH2 can provide compartment context for NADPH generation.
- Somatic mutation and oncology language is outside this inherited-terrain page scope.
- The page does not infer cancer risk, diagnosis, prognosis, or treatment decisions.
Cross-System Connections
Approved seed-graph edges for IDH1/IDH2 are pending curation. This page keeps pathway context visible without inventing factor links.
Connected pools: pending approved graph-edge curation