5-MTHF
1.00xstable
Production validation slice
Metabolic Terrain Console
Toggle seed variants, inspect qualitative pathway pressure, and test the governed evidence prompt interface. Outputs are relative direction and magnitude only.
Raw genetic files stay client-side Server persistence remains gatedPractitioner beta uses synthetic data only
Variant Controls
No genetic file imported. Variant state is browser-session only.
Shareable links encode curated variant states only.
Condition Deep Dives
Terrain Map
Selected Node
MTHFR
gene
methylation cycle
Evidence refs: ev-mthfr-kinetics
Qualitative Flux State
Homocysteine
1.00xstable
SAMe
1.00xstable
SAH
1.00xstable
NADPH
1.00xstable
Reduced glutathione
1.00xstable
MTHFR supports 5-MTHF production1.00x flux
Reduced remethylation pressure raises Hcy risk1.00x flux
CBS routes sulfur toward glutathione synthesis0.60x flux
COMT consumes methyl donors0.35x flux
AHCY clears SAH pressure from methylation turnover0.42x flux
NADK supports NADPH pool capacity0.55x flux
G6PD supports oxidative PPP NADPH generation0.72x flux
Evidence Prompt Gate
MTHFR C677T residual activity and folate-cycle effect: clinical_study
CBS transsulfuration routing and glutathione precursor pressure: mechanistic_inference
COMT methyl donor demand and SAMe competition: mechanistic_inference
AHCY and SAH pressure in methylation turnover: mechanistic_inference
NADK contribution to NADPH pool capacity: mechanistic_inference
G6PD oxidative pentose phosphate pathway NADPH generation: clinical_study