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Methylation cycle
MTHFD1/MTHFD2 One-Carbon Terrain
Folate one-carbon routing context and compartment uncertainty.
Evidence quality visible
No dosing or treatment advice
Terrain context linked
What The Enzyme Does
MTHFD1 and MTHFD2 are represented as one-carbon folate-routing context. Current content stays review-required and qualitative.
- Gene
- Methylenetetrahydrofolate dehydrogenase 1 and 2
- External IDs
- MetaboliQ:condition:mthfd1-mthfd2
What The Variants Change
MTHFD1/MTHFD2 genotype controls remain blocked until curated variants, compartment-specific records, and reviewer signoff exist.
No curated variant control is exposed for MTHFD1/MTHFD2 in Phase 1A.
Downstream Consequences
- One-carbon routing context can inform folate and methylation terrain review.
- Compartment-specific interpretation is not yet graph-grounded.
- The page does not infer folate dosing, cancer risk, fertility outcomes, or treatment response.
Cross-System Connections
Approved seed-graph edges for MTHFD1/MTHFD2 are pending curation. This page keeps pathway context visible without inventing factor links.
Connected pools: pending approved graph-edge curation