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Methylation cycle
MTR/MTRR Remethylation Terrain
B12-dependent remethylation context and methylation-cycle uncertainty.
Evidence quality visible
No dosing or treatment advice
Terrain context linked
What The Enzyme Does
MTR and MTRR are represented as a review-required remethylation node pair. The page frames their role as pathway context for methionine-cycle continuity, not a clinical interpretation surface.
- Gene
- Methionine synthase and methionine synthase reductase
- External IDs
- MetaboliQ:condition:mtr-mtrr
What The Variants Change
MTR and MTRR variants are listed as Phase 2 content targets, but no curated genotype control is exposed until variant records and reviewer signoff exist.
No curated variant control is exposed for MTR/MTRR in Phase 1A.
Downstream Consequences
- Remethylation context is modeled qualitatively as pathway continuity pressure.
- B12-related interpretation remains an evidence-review topic rather than a supplement or protocol recommendation.
- Current content does not infer homocysteine values, methylation status, or clinical action.
Cross-System Connections
Approved seed-graph edges for MTR/MTRR are pending curation. This page keeps pathway context visible without inventing factor links.
Connected pools: pending approved graph-edge curation