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Methylation cycle

MTHFR C677T Terrain

Methylation-cycle pressure, 5-MTHF support, and homocysteine risk context.

Evidence quality visible
No dosing or treatment advice
Terrain context linked

What The Enzyme Does

MTHFR is represented as a methylation-cycle enzyme that supports 5-MTHF production. The current seed graph models MTHFR effects as qualitative relative pathway pressure, not serum values or diagnosis.

Gene
Methylenetetrahydrofolate reductase
External IDs
HGNC:HGNC:7436, NCBI_GENE:4524

What The Variants Change

The Phase 1A genotype control covers MTHFR C677T with documented residual-activity states for wild-type, heterozygous, and homozygous calls.

MTHFR C677T

rs1801133

wt

100% modeled activity

het

65% modeled activity

hom

30% modeled activity

Downstream Consequences

  • Lower modeled MTHFR activity reduces relative 5-MTHF support.
  • Reduced remethylation support increases qualitative homocysteine pressure risk.
  • The current model does not infer methylfolate dosing, treatment, or absolute lab values.

Cross-System Connections

MTHFR supports 5-MTHF production

CATALYZES

MTHFR to five-mthf; qualitative coefficient 1

Reduced remethylation pressure raises Hcy risk

DEPLETES_ACCUMULATES

MTHFR to homocysteine; qualitative coefficient -0.65

Connected pools: 5-MTHF, Homocysteine

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